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March 08, 2021 15:26 IST
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed the mutations
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Artistic 3D-rendering of a T cell fighting with SARS-CoV-2 (not to scale). Credit: Benedikt Agerer / CeMM
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed the mutations Some mutations in the novel coronavirus may not only enable it to evade antibodies, but also make the virus unrecognisable to the immune system s T-killer cells, says a new study which could aid in the further development of vaccines.
While antibodies dock directly onto viruses to neutralise them, the scientists, including those from the Medical University of Vienna in Austria, said the T-killer cells recognise viral protein fragments on infected cells and subsequently kill them to stop virus production.
a recent sudy suggests certain mutations in the novel coronavirus may not only allow it to escape neutralisation but also make the virus unidentifiable to the immune system's T-killer' cells, which could aid in the further development of vaccines.
Some coronavirus mutations may help it evade immune system s T-killer cells, say scientists
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed mutations for their potential to alter T cell epitopes.
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LONDON: Some mutations in the novel coronavirus may not only enable it to evade antibodies, but also make the virus unrecognisable to the immune system s T-killer cells, says a new study which could aid in the further development of vaccines.
While antibodies dock directly onto viruses to neutralise them, the scientists, including those from the Medical University of Vienna in Austria, said the T-killer cells recognise viral protein fragments on infected cells and subsequently kill them to stop virus production.
COVID-19: Immunantwort kann durch Mutationen ausgehebelt werden heilpraxisnet.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from heilpraxisnet.de Daily Mail and Mail on Sunday newspapers.
SARS-CoV-2 can evade immune response by T-killer cells through mutations
The body s immune response plays a crucial role in the course of a SARS-CoV-2 infection. In addition to antibodies, the so-called T-killer cells, are also responsible for detecting viruses in the body and eliminating them.
Scientists from the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna have now shown that SARS-CoV-2 can make itself unrecognizable to the immune response by T-killer cells through mutations.
The findings of the research groups of Andreas Bergthaler, Judith Aberle, and Johannes Huppa provide important clues for the further development of vaccines and were published in the journal