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Hospitalized COVID-19 patients treated with high-titer convalescent plasma showed no survival benefits or clinical improvements compared to patients only receiving usual care, according to data from the U.K. s RECOVERY trial.
Both groups had a mortality rate of 24% at 28 days (RR 1.00 95% CI 0.93-1.07,
P=0.95), reported Peter Horby, PhD, of the University of Oxford in England, and colleagues.
There was also no difference between groups in hospital stay duration or chance of disease progression, the authors wrote in This study is significant since the Recovery Collaborative Group organized the largest randomized trial in reporting COVID-19 convalescent therapy mortality results, Horby and colleagues wrote.
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Convalescent plasma given to hospitalized COVID-19 patients did not improve survival or rates of release from the hospital within 28 days, need for invasive mechanical ventilation, or death, according to the most recent findings of the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial in the United Kingdom.
The results, published late last week in
The Lancet, add to evidence that SARS-CoV-2 antibody-rich plasma taken from COVID-19 survivors doesn t benefit severely ill coronavirus patients. The RECOVERY trial is evaluating several possible treatments for hospitalized COVID-19 patients at 177 National Health Services sites.
Death, mechanical ventilation, hospital release
The researchers assigned 11,558 patients to receive either convalescent plasma or usual care in a 1:1 ratio from May 28, 2020, to Jan 15, 2021.