Theoretical physicists at Goethe University Frankfurt have analysed data from the black hole M87 as part of the Event Horizon Telescope (EHT) collaboration to test Albert Einstein s theory of general relativity. According to the tests, the size of the shadow from M87 is in excellent agreement being from a black hole in general relativity, but sets constraints on the properties of black holes in other theories.
Whether bacteria are resistant to antibiotics is often decided at the cell membrane. This is where antibiotics can be blocked on their way into the cell interior or catapulted from the inside to the outside. Macrocyclic peptides, a novel class of antibiotics, bioactive cytotoxins and inhibitors, shed light on how this transport process occurs at the membrane, how it is influenced and how it can be used to circumvent the resistance of a malignantly transformed cell.
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Researchers discover the second possible effective mechanism of remdesivir
The virostatic agent remdesivir was developed to disrupt an important step in the propagation of RNA viruses, to which SARS-CoV-2 also belongs: the reproduction of the virus s own genetic material. This is present as RNA matrices with which the host cell directly produces virus proteins.
To accelerate the production of its own proteins, however, RNA viruses cause the RNA matrices to be copied. To do so, they use a specific protein of their own (an RNA polymerase), which is blocked by remdesivir. Strictly speaking, remdesivir does not do this itself, but rather a substance that is synthesized from remdesivir in five steps when remdesivir penetrates a cell.