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Researchers unravel mechanisms that produce individualized metabolism in leukemia A research collaboration based in Kumamoto University (Japan) has shown that lysine-specific demethylase 1 (LSD1), an enzyme involved in gene expression, produces individualized metabolism depending on the type of acute myeloid leukemia cells. Cancer cells are known to have a unique ability to metabolize substances differently from normal cells, and this ability is considered to be a promising therapeutic target. The new research findings may contribute to the safe and effective use of LSD1 inhibitors as potential anticancer agents, and to the development of highly specific treatments for various leukemia types. Acute myelogenous leukemia (AML) occurs when hematopoietic stem cells become tumors rather than differentiating into white or red blood cells. The various types of AML develop according to which stage of differentiation they become cancerous. Those that develop when differentiating into red bl

Shinjiro hinoEmily hendersonCancer researchKumamoto universityNature communicationsKumamoto university japanNucleic acids researchAssociate professor shinjiro hinoஎமிலி ஹென்டர்சன்புற்றுநோய் ஆராய்ச்சிகுமாமோடோ பல்கலைக்கழகம்இயற்கை தகவல்தொடர்புகள்குமாமோடோ பல்கலைக்கழகம் ஜப்பான்