Reactive Astrocytes Boot Basic, Dysfunctional Lysosomes alzforum.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from alzforum.org Daily Mail and Mail on Sunday newspapers.
Image credit: Kampmann Lab
When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in
Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome.
In doing so, they’ve created a technique that can be employed for many different cell types, as well as a database where other researchers using the new technique can contribute similar knowledge, creating a picture of gene function in disease across the entire spectrum of human cells.
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IMAGE: Super-resolution microscopy of a neuron shows the accumulation of lipids within lysosomes that occurs when the gene for prosaposin is suppressed. view more
Credit: UCSF
When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in
Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome.
In doing so, they ve created a technique that can be employed for many different cell types, as well as a database where other researchers using the new technique can contribute similar knowledge, creating a picture of gene function in disease across the entire spectrum of human cells.
21 Jan 2021
As Alzheimer’s tangle pathology progresses, neurodegeneration sweeps through the brain in a stereotypical fashion. But why do some neurons perish early on, while their neighbors persist until the bitter end? A study published January 11 in Nature Neuroscience addressed this question by tracing the gene-expression profiles of neurons in the brains of people who died in the early or late stages of the disease. Among myriad subpopulations of cells, the researchers zeroed in on subsets of excitatory neurons that express the transcription factor RORB as the first to succumb. Initially in the entorhinal cortex, and then later in the outer neocortex, excitatory neurons bearing this particular marker were selectively vulnerable to tau accumulation, and to death. The study, led by Lea Grinberg and Martin Kampmann, both at the University of California, San Francisco, also pegged a type of reactive astrocyte that may shirk its duties of protecting and nourishing neurons. In all,
Hallan las células cerebrales más vulnerables al Alzheimer invdes.com.mx - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from invdes.com.mx Daily Mail and Mail on Sunday newspapers.