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L’occhio Della Mosca (
The Fly’s Eye) by Giambattista Odierna in 1644 CE. In that sensational book, the Italian naturalist provided the first detailed account of organic tissue – enabled by studying organic matter under the lens of newly invented microscopes. Now, the latest optical microscope technology is capable of imaging viruses that live in organisms.
Conventional Light Microscopes: Widefield and Confocal
Conventional light microscopes – widefield and confocal optical microscopes – can accurately depict image samples at resolutions of around 230 nm (widefield) or 180 nm (confocal) in the XY axes. On the Z-axis (analogous to focal length in photography), these traditional microscopy methods work at resolutions of around 1000 nm (widefield) or 500 nm (confocal).
Biodegradable Nanoprobes Improve Cancer Diagnosis
Written by AZoNanoMar 12 2021
New nanoprobes, which were recently developed by Imperial College London (ICL) and tested in zebrafish, could help identify cancer more precisely and may support the diagnosis and treatment in the days to come.
Purple cancer cells are labeled using bioharmonophores (white label). Image Credit: Imperial College London.
To clearly visualize tumors in the body for cancer diagnosis, physicians can utilize miniature optical probes (nanoprobes) that illuminate upon binding to tumors. Such nanoprobes enable doctors to detect the size, shape and location of tumors in the body.
The majority of the nanoprobes are fluorescent, which means they absorb light of a particular color, such as blue, and then produce a background light of a different color, such as green.