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Study Suggests Way to Boost Immunotherapy Against Breast Cancer, Other Solid Tumors

Study Suggests Way to Boost Immunotherapy Against Breast Cancer, Other Solid Tumors
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Jonathans serodyLineberger comprehensive cancer centerImmunotherapy programComprehensive cancerElizabeth thomas professorலிநேபேர்கேற் விரிவான புற்றுநோய் மையம்நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம்விரிவான புற்றுநோய்எலிசபெத் தாமஸ் ப்ரொஃபெஸர்

Combined approach could boost breast cancer immunotherapy, study suggests

E-Mail IMAGE: A diagram showing the various strategies that could enhance the activity of CAR T cells against breast cancer. view more Credit: © 2020 Xu et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20200844 Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of genetically engineered T cells to eradicate breast cancer in mice, according to a new study by researchers at the University of North Carolina. The study, to be published December 31 in the JEM), suggests that CAR T cells, which are already used to treat certain blood cancers in humans, may also be successful against solid tumors if combined with other immunotherapeutic approaches.

Jonathans serodyRockefeller universityUniversity of north carolina school medicineUniversity of north carolinaCellular therapy programExperimental medicineElizabeth thomas professorNorth carolina schoolராக்ஃபெல்லர் பல்கலைக்கழகம்பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா பள்ளி மருந்துபல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினாசெல்லுலார் சிகிச்சை ப்ரோக்ர்யாம்சோதனை மருந்துஎலிசபெத் தாமஸ் ப்ரொஃபெஸர்வடக்கு கரோலினா பள்ளி

Study points the way to boost immunotherapy against breast cancer, other solid tumors

E-Mail IMAGE: UNC Lineberger Comprehensive Cancer Center s Jonathan S. Serody, MD, and colleagues report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T. view more Credit: UNC Lineberger Comprehensive Cancer Center CHAPEL HILL, NC Boosting immune system T cells to effectively attack solid tumors, such as breast cancers, can be done by adding a small molecule to a treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy, according to a study by researchers at the UNC Lineberger Comprehensive Cancer Center. The boost helps recruit more immune cells into battle at the tumor site. The findings are published in the

United statesSmith klineSoniaj laurieNicholasp restifoJonathans serodyBenjamin vincentDouglasc palmerCaryn willisAlexanderc robesonHemamalini bommiasamySchool of medicineLyell immunophara incNational cancer instituteUniversity cancer research fundMerck incLineberger comprehensive cancer center