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Findings from a new University of Kentucky College of Medicine study published in the Journal of Biological Chemistry May 28 may lead to a new treatment against Toxoplasma gondii, the parasite that causes toxoplasmosis. The labs of Matthew Gentry, Ph.D., and Craig Vander Kooi, Ph.D., in the Department of Molecular and Cellular Biochemistry, Anthony Sinai, Ph.D., in the Department of Microbiology, Immunology and Molecular Genetics, and Zhong-Yin Zhang, Ph.D., at the Purdue Institute for Drug Discovery, collaborated to develop a drug that targets the cyst form of the parasite. Dr. Greg talks with Gentry about the breakthrough research.
Those who have severe toxoplasmosis can harbor a cyst version of the parasite within brain and muscle tissue. These cysts are responsible for causing serious disease, especially in people who are immunocompromised.