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Study on largest genetic risk factor for Alzheimer s points toward new drug target

Study on largest genetic risk factor for Alzheimer s points toward new drug target
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San franciscoUnited statesNicole koutsodendrisYadong huangUniversity of californiaCell reportsGladstone institutesGladstone investigator yadong huang

Study on largest genetic risk factor for Alzh

<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>

Mission bayUnited statesSan franciscoOscar yipNicole koutsodendrisYanxia haoSeo yeon yoonMisha zilberterPatrick arriolaMichela tragliaMaxiner nelsonReuben thomasAntara raoYadong huangAayushi agrawalJessica blumenfeld

A Man s Rare Genetic Mutation May Have Prevented Alzheimer s for Decades | Smart News

Scientists hope the findings could lead to treatments for the memory-destroying disease

District of columbiaUnited statesNew yorkNordrhein westfalenCarolyny johnsonDiego sepulveda fallaCatherine kaczorowskiYadong huangAndrew josephClare wilsonNewssara reardonRudolph tanziGina kolataNikolas robakisWashington postNational institute on

US Man Immune To Alzheimer s Disease, Gene Mutation Delays The Disease By 20 Years

This is the world's second such case. But the man belongs to the same family of which 6,000 family members carry the gene presenilin-1, or PSEN1 commonly known to raise risk of Alzheimer's., Health News, Times Now

United statesSan franciscoNew yorkJoseph arboleda velasquezKadi pattaYadong huangSurprising healthHarvard medical schoolDrug administrationNature medicineHealth benefits of kadiMassachusetts eyeHarvard medicalGladstone institutesAlzheimer x27s diseaseAlzheimer x27 s

How One Man s Rare Alzheimer s Mutation Delayed the Onset of Disease

Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments

Ann arborUnited statesSan franciscoJoseph arboledaYadong huangFrancisco loperaCatherine kaczorowskiHarvard medical schoolDrug administrationUniversity of antioquiaUniversity of michiganNature medicineGladstone institutes