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Christchurch Mutation – How Good Can Overpower Evil in Alzheimer s Disease Genetics

New research sheds light on protective mechanisms of the “Christchurch mutation.” Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most co

Universidad de antioquiaNew zealandUnited statesReuben thomasTenzing choenyiJosephf arboleda velasquezOscar yipYakeelt quirozRobertw mahleyEric reimanJessica blumenfeldSeo yeon yoonRobert mahleyMaxiner nelsonMichela tragliaJoseph arboleda velasquez

Study On Largest Genetic Risk Factor For Alzheimer s Points Toward New Drug Target – Eurasia Review

Study On Largest Genetic Risk Factor For Alzheimer s Points Toward New Drug Target – Eurasia Review
eurasiareview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurasiareview.com Daily Mail and Mail on Sunday newspapers.

United statesSan franciscoNicole koutsodendrisYadong huangUniversity of californiaGladstone institutesCell reportsGladstone investigatorComes firstNew drug

Study on largest genetic risk factor for Alzheimer s points toward new drug target

Study on largest genetic risk factor for Alzheimer s points toward new drug target
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

San franciscoUnited statesNicole koutsodendrisYadong huangUniversity of californiaCell reportsGladstone institutesGladstone investigator yadong huang

Study on largest genetic risk factor for Alzh

<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>

Mission bayUnited statesSan franciscoOscar yipNicole koutsodendrisYanxia haoSeo yeon yoonMisha zilberterPatrick arriolaMichela tragliaMaxiner nelsonReuben thomasAntara raoYadong huangAayushi agrawalJessica blumenfeld

Gladstone researchers shine a brighter spotlight on key Alzheimer s protein produced by neurons

Of all the known genetic risk factors for late-onset Alzheimer's disease, the strongest is a gene for the protein called ApoE4.

United statesNicole koutsodendrisYadong huangEmily hendersonGladstone institutesNature agingGladstone senior investigatorNorth americansTranslational advancementDiscovery industry focusStem cell biologyBrain cellLzheimer 39s disease