In this new article publication from Acta Pharmaceutica Sinica B, authors Ting Lei, Zhihang Yang, Xue Xia, Yuxiu Chen, Xiaotong Yang, Rou Xie, Fan Tong, Xiaolin Wang, Huile Gao from Sichuan University, Chengdu, China and Macau University of Science and Technology, Macau, China discuss how nanocleaners can specifically penetrate the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease.
Florida State University News
Faculty and Staff Briefs: February 2021
Published:
HONORS AND AWARDS
The FSU Alumni Association was recognized with a 2021 CASE District III award and received Grand Gold in the category of Alumni/General Interest Magazines produced two times per year for its biannual alumni publication, VIRES magazine.
Mackenzie Alston, Ph.D. (Department of Economics) was selected for a post-doctoral fellowship from the National Bureau of Economic Research (NBER) to support diversity in economics. The one-year fellowship is open to early-career economists from historically underrepresented demographics within the economics profession and to researchers studying diversity issues.
Alex Meyer, Ph.D. (Department of Psychology) received an award for Distinguished Early Career Contribution to Psychophysiology from the Society for Psychophysiological Research.
Wayne Lewis |
FINDINGS
Research led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings.
They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes.
In addition, they revealed how the toxin molecule causes inflammation, which has been a long-standing mystery because such molecules are generally quickly digested in the gut. The scientists found that toxin A and surprisingly even fragments of the toxin can organize DNA into ordered crystalline particles that amplify an immune response by binding to multiple TLR9 recept
New details about how bacterial toxins cause life-threatening colitis
January 8, 2021ScienceBlog.com
Research led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings.
They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes.
In addition, they revealed how the toxin molecule causes inflammation, which has been a long-standing mystery because such molecules are generally quickly digested in the gut. The scientists found that toxin A and surprisingly even fragments of the toxin can organize DNA into ordered crystalline particles