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How Inhibition of Enzyme Leads to the Development of Alzheimer s Analyzed by Angela Mohan on  April 21, 2021 at 5:12 PM Meprin β releases proteins from cell membranes, controlling important physiological functions in the human body. But, a dysregulation of this process can trigger the development of Alzheimer s and cancer. Meprin β is regulated by fetuin-B binding to the enzyme when required, thereby preventing the release of other proteins, as per the findings in the journal Proceedings of the National Academy of Sciences . Research team produced meprin β and fetuin-B in insect cells and then allowed them to react with one other in a test tube. Using enzyme kinetics and biophysical analyses, the researchers determined that this reaction resulted in an exceptionally stable, high-molecular-mass complex.

Proceedings of the national academy sciencesNational academyAlzheimers diseaseEtuin bEprin bComputer modelX ray crystallographyCell membranesதேசிய கலைக்கழகம்அல்சைமர் நோய்