How Inhibition of Enzyme Leads to the Development of Alzheimer's Analyzed
by Angela Mohan on
April 21, 2021 at 5:12 PM
Meprin β releases proteins from cell membranes, controlling important physiological functions in the human body. But, a dysregulation of this process can trigger the development of Alzheimer's and cancer.
Meprin β is regulated by fetuin-B binding to the enzyme when required, thereby preventing the release of other proteins, as per the findings in the journal
"Proceedings of the National Academy of Sciences".
Research team produced meprin β and fetuin-B in insect cells and then allowed them to react with one other in a test tube. Using enzyme kinetics and biophysical analyses, the researchers determined that this reaction resulted in an exceptionally stable, high-molecular-mass complex.