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Credit: Children s Hospital of Philadelphia Philadelphia, January 13, 2021 Researchers at Children s Hospital of Philadelphia and the School of Engineering and Applied Science at the University of Pennsylvania have identified ionizable lipid nanoparticles that could be used to deliver mRNA as part of fetal therapy. The proof-of-concept study, published today in Science Advances, engineered and screened a number of lipid nanoparticle formulations for targeting mouse fetal organs and has laid the groundwork for testing potential therapies to treat genetic diseases before birth. This is an important first step in identifying nonviral mediated approaches for delivering cutting-edge therapies before birth, said co-senior author William H. Peranteau, MD, an attending surgeon in the Division of General, Thoracic and Fetal Surgery and the Adzick-McCausland Distinguished Chair in Fetal and Pediatric Surgery at CHOP. These lipid nanoparticles may provide a platform for in utero mRNA del

University of pennsylvaniaUnited statesApplied scienceWilliamh peranteauMichaelj mitchellSchool of engineeringScience advancesFetal surgeryAdzick mccausland distinguished chairPediatric surgerySkirkanich assistant professorPenn engineeringLipid nanoparticlesMedicine healthGene therapyNanotechnology micromachines