Credits: Courtesy of the researchers Terms of Use: Images for download on the MIT News office website are made available to non-commercial entities, press and the general public under a Creative Commons Attribution Non-Commercial No Derivatives license. You may not alter the images provided, other than to crop them to size. A credit line must be used when reproducing images; if one is not provided below, credit the images to MIT. Caption: MIT biologists have found a possible explanation for the Warburg effect, first seen in cancer cells in the 1920s and named after Otto Warburg, pictured. Credits: Image: Digital collage by Jose-Luis Olivares; cancer image courtesy of Dr. Cecil Fox, NCI; Warburg photo courtesy of NIH
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Metabolic Limitations in Cancer
All cells in the body, including cancer cells, exist in different metabolic environments, and thus have different nutritional resources available to them, said
Mathew Vander Heiden. Cancer cells have especially high metabolic needs because by definition, they proliferate doubling the mass of proteins, nucleic acids, and lipids in order to go from one cell to two. Understanding how different types of cancer cells reorganize their metabolic pathways to accomplish this feat can bring insight into the role metabolism plays in cancer therapeutics.
Tissues solve their metabolic needs differently. Metabolism in brain cells, for example, differs from that in liver cells. These differences must be reflected in the gene expression patterns of the tissues’ metabolic networks. When a cell becomes cancerous, it takes its existing metabolic network, based on its environment, and reorganizes it to support its proliferation. That’s why cancers ex
Laura McKnight
Jeff McKnight, a molecular biologist at the University of Oregon, died in October at the age of 36.
McKnight’s research focused on chromatin, a complex of DNA and proteins that controls when and how DNA can be accessed for replication and gene expression. He was one of the earliest researchers in the world capable of directly manipulating its structure, stemming back to his postdoctoral work at the Fred Hutchinson Cancer Research Center using the model organism
Saccharomyces cerevisiae. When he had started his own lab in 2016, McKnight said at the time that his “real dream” was to apply his work to the dozens of human diseases that involve some level of chromatin disruption, including Parkinson’s, Alzheimer’s, and Huntington’s.
hands on writings of death inmate robert shermantine, who some believe to be responsible for up to 25 deaths. i think they re just a human [ bleep ] and that s all i can say. reporter: among the dead, van der sloot van der heiden. they discovered her bones. this will put it to rest so friends and family can, you know, pay their respects. vander heiden has kept his porch light on for 14 years, hoping his daughter would come home. he s sickened by the discovery of more bones and knows exactly what the families of other victims who are now waiting for news are going through. you never forget. you think of her constantly. that s you never it never goes away. reporter: so far two victims whose remains were found in caliveras have been preliminarily identified through dental records. it s unclear how long it s going to take to identify more victims. it s also unclear tonight if and when investigators are going to start searching that second well. they say they pla