Latest ‘organ-on-a-chip’ is a new way to study cancer-related muscle wasting
Studying drug effects on human muscles just got easier thanks to a new “muscle-on-a-chip,” developed by a team of researchers from Penn’s School of Engineering and Applied Science and Inha University in Incheon, Korea. Bioengineering’s Dan Huh and colleagues have developed a number of organ-on-a-chip devices to simulate how human cells grow and perform in their natural environments. Their latest is a muscle-on-a-chip, which carefully captures the directionality of muscle cells as they anchor themselves within the body. (Image: Melissa Pappas).
Muscle tissue is essential to almost all of the body’s organs, however, diseases such as cancer and diabetes can cause muscle tissue degradation or “wasting,” severely decreasing organ function and quality of life. Traditional drug testing for treatment and prevention of muscle wasting is limited through animal studies
Paving the way for new light-powered devices By combining cutting-edge concepts from theoretical physics, researchers from Penn Engineering developed ‘sypersymmetric microlaser arrays’ that are both stable and have high power density.
The field of photonics involves the study of new ways to generate and harness light, akin to how many of the devices used in everyday life run on electric current. While photonic devices have the potential to transform the current technology paradigm through increased speed, efficiency, and information density, their broad application is limited by the size, strength, and stability of the light sources, often lasers, in these devices.
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Sixty percent of survey respondents who identified as African American or Black reported that someone once claimed their racial identity unfairly contributed to their acceptance to the Engineering School, in comparison to 7.81% of Asian and 7.58% of white respondents.
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