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Date Time How diet controls RNA maturation Two UNIGE teams have discovered a new mechanism for regulating RNA maturation that depends on diet. The nematode C. elegans at two developmental stages: a larva and a developing embryo. © Joanna Wenda Particularly sensitive to chemical modifications, messenger RNAs (mRNAs) are molecules responsible for transmitting the information encoded in our genome, allowing for the synthesis of proteins, which are necessary for the functioning of our cells. Two teams from the University of Geneva (UNIGE), Switzerland, in collaboration with the Norwegian University of Science and Technology (NTNU), have focused on a specific type of chemical modification – called methylation – of mRNA molecules in the small worm Caenorhabditis elegans. They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm’s diet. These findings are to be read in the journal Cell.

Mateusz mendelRamesh pillaiJoanna wendaUeli schiblerFlorian steinerDepartment of molecular biologyUniversity of genevaNorwegian university of scienceNorwegian universityMolecular biologyKamila delaneyரமேஷ் பிள்ளைபுளோரியன் ஸ்டீனர்துறை ஆஃப் மூலக்கூறு உயிரியல்பல்கலைக்கழகம் ஆஃப் ஜிநீவநோர்வே பல்கலைக்கழகம் ஆஃப் அறிவியல்