How diet controls RNA maturation

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How diet controls RNA maturation
Two UNIGE teams have discovered a new mechanism for regulating RNA maturation that depends on diet.
The nematode C. elegans at two developmental stages: a larva and a developing embryo. © Joanna Wenda
Particularly sensitive to chemical modifications, messenger RNAs (mRNAs) are molecules responsible for transmitting the information encoded in our genome, allowing for the synthesis of proteins, which are necessary for the functioning of our cells. Two teams from the University of Geneva (UNIGE), Switzerland, in collaboration with the Norwegian University of Science and Technology (NTNU), have focused on a specific type of chemical modification – called methylation – of mRNA molecules in the small worm Caenorhabditis elegans. They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm’s diet. These findings are to be read in the journal Cell.

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Norway ,Switzerland ,Norwegian ,Mateusz Mendel ,Ramesh Pillai ,Joanna Wenda ,Ueli Schibler ,Florian Steiner ,Department Of Molecular Biology ,University Of Geneva ,Norwegian University Of Science ,Norwegian University ,Molecular Biology ,Kamila Delaney ,நோர்வே ,சுவிட்சர்லாந்து ,ரமேஷ் பிள்ளை ,புளோரியன் ஸ்டீனர் ,துறை ஆஃப் மூலக்கூறு உயிரியல் ,பல்கலைக்கழகம் ஆஃப் ஜிநீவ ,நோர்வே பல்கலைக்கழகம் ஆஃப் அறிவியல் ,நோர்வே பல்கலைக்கழகம் ,மூலக்கூறு உயிரியல் ,