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Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

Hong kongChe chi mingHuang yuanhuaStephanie ma kwai yeeEmily hendersonJaved asifGuang shengLok chun namTeo jia ming nickolasChen weixinTechnology parks corporationDepartment of chemistryUniversity of hong kong hkumedSchool of biomedical sciencesKey laboratory of synthetic chemistryTypei interferon

HKUMed Finds Unexpected T Cell Exhaustion Factor in Cancer Immunotherapy Resistance

HKUMed Finds Unexpected T Cell Exhaustion Factor in Cancer Immunotherapy Resistance
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Hong kongChe chi mingHuang yuanhuaStephanie ma kwai yeeJaved asifVictor grayGuang shengLok chun namTeo jia ming nickolasChen weixinTechnology parks corporationDepartment of chemistryResearch fellow schemeUniversity of hong kong hkumedSchool of biomedical sciencesKey laboratory of synthetic chemistry

Discovering Genetic Variants that Significantly Predispose People to Critical COVID-19

We speak with postdoctoral researcher Erola Pairo-Castineira about her recent work which aimed to find the genetic factors that may predispose individuals to critical COVID-19 and learn how COVID-19 affects cells in the body.

United kingdomCity ofErola pairo castineiraThanapipat kulmuangdoan shutterstockDanielle ellisRoslin instituteLeaderserola pairo castineirapostdoctoral researcherroslin instituteUniversity of edinburghProfessor baillieImage creditWhole genomeInterferon type iTypei interferonEne expressionIntensive careArs cov 2

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

What is going on at the single-cell level in the first days of SARS-CoV-2 infection in the lungs?

San antonioUnited statesDeepak kaushalDhirajk singhShabaana khaderEmily hendersonMaxim artyomovResearchers at texas biomedical research instituteNational primate research centerNature communicationsSan antonio medical foundationNational institutes of healthOffice of research infrastructure programsWashington university in stTexas biomedical research instituteSouthwest national primate research center

Initial Covid infection on single-cell level, revealed

SAN ANTONIO (February 8, 2022) – What is going on at the single-cell level in the first days of SARS-CoV-2 infection in the lungs? Researchers at

San antonioUnited statesDeepak kaushalDhirajk singhShabaana khaderMaxim artyomovResearchers at texas biomedical research instituteNational primate research centerNature communicationsSan antonio medical foundationNational institutes of healthOffice of research infrastructure programsWashington university in stTexas biomedical research instituteSouthwest national primate research centerWashington university