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Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

HKUMed Finds Unexpected T Cell Exhaustion Factor in Cancer Immunotherapy Resistance

HKUMed Finds Unexpected T Cell Exhaustion Factor in Cancer Immunotherapy Resistance
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New Uses of Old Drugs: Silver Nitrate with More Than 2,000 Years Antimicrobial History Can Re-sensitise the Last-line Antimicrobial Colistin in Combination Therapy against Superbugs

HKU chemists develop a new drug discovery strategy for

 E-Mail IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery. view more  Credit: The University of Hong Kong A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells. Membrane proteins play important roles in biology, and many of them are high-value targets that are being intensively pursued in the pharmaceutical industry. The method developed by Dr Li s team provides an efficient way to discover novel ligands and inhibitors against membrane proteins, which remain largely intract

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