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mCRC Treatment Sequencing Influenced By Combination Therapy

A recent FDA-approval is examined that provides new opportunities for effective combination strategies in mCRC treatment.

#VisualAbstract: Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer

Click here to read this study in NEJM. ©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Trifluridine–Tipiracil and Bevacizumab Improves Survival in Metastatic Pretreated Colorectal Cancer

1. The median overall survival was 10.8 months in the combination group (FTD–TPI + bevacizumab) and 7.5 months in the FTD–TPI alone group, with HR 0.61. 2. The most common adverse events in both groups included neutropenia, nausea, and anemia. Evidence Rating Level: 1 (Excellent) Study Rundown: Trifluridine-tipiracil (cytotoxic nucleic acid analogue) is commonly used

FDA Grants Priority Review to TAS-102 Plus Bevacizumab for Refractory mCRC

The FDA has accepted for priority review the supplemental new drug application seeking the approval of trifluridine/tipiracil as a single agent or in combination with bevacizumab for use in select patients with refractory, metastatic colorectal cancer.

XBiotech Announces First Patient Enrolled into the French National Cancer Institute (INCA) Sponsored Phase I/II/III Clinical Study for Natrunix™ Therapy for Colorectal Cancer

XBiotech Announces First Patient Enrolled into the French National Cancer Institute (INCA) Sponsored Phase I/II/III Clinical Study for Natrunix™ Therapy for Colorectal Cancer
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