Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery job in Ann Arbor, Michigan with University of Michigan - Department of Pathology. Apply Today.
Michigan Drug Discovery aids new projects to treat obesity, cancer umich.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from umich.edu Daily Mail and Mail on Sunday newspapers.
E-Mail
IMAGE: An X-ray crystallography image showing an ASH1L inhibitor developed at U-M in complex with the protein. view more
Credit: Grembecka / Cierpicki Labs
The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases. The ASH1L protein, however, has been challenging to target therapeutically.
Now a team of researchers led by Jolanta Grembecka, Ph.D., and Tomasz Cierpicki, Ph.D., from the University of Michigan has developed first-in-class small molecules to inhibit ASH1L s SET domain preventing critical molecular interactions in the development and progression of leukemia.