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 E-Mail There is no stronger risk factor for cancer than age. At the time of diagnosis, the median age of patients across all cancers is 66. That moment, however, is the culmination of years of clandestine tumor growth, and the answer to an important question has thus far remained elusive: When does a cancer first arise? At least in some cases, the original cancer-causing mutation could have appeared as long as 40 years ago, according to a new study by researchers at Harvard Medical School and the Dana-Farber Cancer Institute. Reconstructing the lineage history of cancer cells in two individuals with a rare blood cancer, the team calculated when the genetic mutation that gave rise to the disease first appeared. In a 63-year-old patient, it occurred at around age 19; in a 34-year-old patient, at around age 9.

United statesDana farber cancer instituteDaniel deangeloEric winerDebra van egerenMarlise luskinMartha wadleighRichard stoneFranziska michorSachin patelMaria kalyvaAnn mullallyChristopher reillyJacqueline garciaGabriela hobbsShichen liu