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Optimizing Afatinib Use: Dosing Strategies and Adverse Event Management

Explore dosing nuances and adverse event management strategies for afatinib in treating EGFR mutant non-small cell lung cancer, reflecting real-world practices and clinical insights.

Precision medicineBiomarker testingAfatinib useDosing strategiesAdverse eventNon small cell lung cancerAfatinib dosingEgfr mutant nsclcAdverse event managementDose modificationPerformance statusLung cancer treatmentPersonalized medicinePrecision oncologyTki therapy

Ponatinib Advances as Frontline Therapy in Ph+ ALL: PhALLCON Study Highlights

Bijal Shah, MD, MS, and Hagop Kantarjian, MD, discuss promising results and regulatory progress for ponatinib in frontline Philadelphia-positive acute lymphoblastic leukemia treatment.

Bijal shahHagop kantarjianExpert insightsNewly diagnosedFrontline therapyAcute lymphoblastic leukemiaCall cancerOph allPh acute lymphoblastic leukemiaPhiladelphia chromosome positive acute lymphoblastic leukemiaNewly diagnosed allNewly diagnosed acute lymphoblastic leukemiaTki therapyComparative trialsHypercvad therapyBroad acting tki

First Report of PhALLCON: A Phase 3 Study Comparing Ponatinib vs Imatinib in Newly Diagnosed Ph+ ALL

Expert Elias Jabbour, MD, reviews clinical data from the PhALLCON study of ponatinib vs imatinib in patients with Ph+ acute lymphocytic leukemia and considers its clinical implications.

Elias jabbourFirst reportComparing ponatinibNewly diagnosedAcute lymphocytic leukemiaCall cancerAll leukemiaPh positiveOph allTyrosine kinase inhibitorsTki therapyCombination therapyBcr ablPonatinib dosePonatinib dosingComplete response

Novel Combination Strategies in mCRC: The STELLAR-303 and SUNLIGHT Trials

Before closing out their review of combination therapy in metastatic colorectal cancer, panelists discuss the STELLAR-303 and SUNLIGHT clinical trials.

Metastatic colorectal cancer withPositive diseaseCombination strategiesColorectal cancerMetastatic crcImmune checkpoint inhibitorsTki therapyTyrosine kinase inhibitorsStellar 303Sunlight trialCombination therapy

Combination IO/TKI Strategies in Metastatic Colorectal Cancer

A comprehensive review on combination strategies with immune checkpoint and tyrosine kinase inhibitors in patients with metastatic colorectal cancer.

Metastatic colorectal cancer withPositive diseaseMetastatic colorectal cancerColorectal cancerMetastatic crcImmune checkpoint inhibitorsTki therapyTyrosine kinase inhibitorsLeap 005Leap 017Cosmic 021Combination therapy

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