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New insights into how South African SARS-CoV-2 variant sacrifices tight binding for antibody evasion The highly infectious SARS-CoV-2 variant that recently emerged in South Africa, known as B.1.351, has scientists wondering how existing COVID-19 vaccines and therapies can be improved to ensure strong protection. Now, researchers reporting in ACS Journal of Medicinal Chemistry have used computer modeling to reveal that one of the three mutations that make variant B.1.351 different from the original SARS-CoV-2 reduces the virus binding to human cells but potentially allows it to escape some antibodies. Since the original SARS-CoV-2 was first detected in late 2019, several new variants have emerged, including ones from the U.K., South Africa and Brazil. Because the new variants appear to be more highly transmissible, and thus spread rapidly, many people are worried that they could undermine current vaccines, antibody therapies or natural immunity.

South africaTien huynhBinquan luanEmily hendersonMedicinal chemistryஎமிலி ஹென்டர்சன்மருத்துவ வேதியியல்