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Loading video. VIDEO: Volumetric reconstruction of the L4 C. elegans neuropil (from EM serial sections) with neurons from the four strata highlighted (S1-Red, S2-Purple, S3-Blue, S4-Green). view more  Credit: Mark Moyle et al., Nature, 2021. WOODS HOLE, Mass. Understanding how the brain works is a paramount goal of medical science. But with its billions of tightly packed, intermingled neurons, the human brain is dauntingly difficult to visualize and map, which can provide the route to therapies for long-intractable disorders. In a major advance published next week in Nature, scientists for the first time report the structure of a fundamental type of tissue organization in brains, called neuropil, as well as the developmental pathways that lead to neuropil assembly in the roundworm

New yorkUnited statesWoods holeMarine biological laboratoryJohn whiteAbhishek kumarSydney brennerZhirong baoWilliama mohlerSmita krishnaswamyMark moyleHari shroffDevelopment of the nerve ringYale school of medicineNational institute of biomedical imagingUniversity of connecticut health center