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Cutting the cable between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor.

Irvine schoolUnited statesFrancesco marangoniShannon geelsMultiscale cell fate researchUc irvine school of medicineUniversity of californiaSaint john cancer institute in santa monicaDepartment of physiology biophysicsUniversity of alabama at birminghamInstitute for immunologyHarvard medical schoolCancer cellComplex biological systemsSimons centerSaint john

Scientists develop x-ray vision technique t

Scientists develop x-ray vision technique t
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Sanjib paulAdam hauserStefano sacannaShihao zangGlen hockySimons centerYork universityNational institute of healthUs army research officeNew york universityComputational physical chemistryResearch officeNational institutePerformance computing

berkeley.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from berkeley.edu Daily Mail and Mail on Sunday newspapers.

United statesNew yorkHarvard universityRepublic ofIvanovskaya oblastStony brookElizabeth costelloShiing shen chernDavid eisenbudBarbara simonsShafi goldwasserMark heisingCarol christBertram kostantKelley coxLaura baxter simons

Ketamine Decoded: New Study Sheds Light on Its Powerful Brain and Mood Effects

Ketamine Decoded: New Study Sheds Light on Its Powerful Brain and Mood Effects
scitechdaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scitechdaily.com Daily Mail and Mail on Sunday newspapers.

United statesBoston universityHarvard universityMendel rosenblumMichellem mccarthyMichelle mccarthyEdward hood taplinBill swansonMimi jensenEarlk millerDianeb greeneGeorgej elbaumElie adamNancy kopellOluwaseun akejuMarek kowalski

Study models how ketamine s molecular action leads to its effects on the brain

New research addresses a gap in understanding how ketamine s impact on individual neurons leads to pervasive and profound changes in brain network function.

United statesHarvard universityBoston universityDianeb greeneElie adamEarlk millerGeorgej elbaumMichelle mccarthyOluwaseun akejuNancy kopellMarek kowalskiMimi jensenEdward hood taplinBill swansonMendel rosenblumEmeryn brown