Toronto, ON (PRWEB) May 15, 2023 The promise of machine learning to dramatically reduce timelines in a lengthy drug discovery process is exciting, but it
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Oligonucleotide ADC Design and Development – An Emerging Field Building on the Success of ADCs in Cancer, Upcoming Webinar Hosted by Xtalks
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In this free webinar, the featured speakers will provide an overview of the challenges and offer solutions for the application of next-generation technologies in the production of ADCs and oligonucleotide conjugates. Attendees will learn about the complexities of ADC construction and bioconjugate drug development with a particular focus on the emerging class of oligonucleotide conjugates.
As AOC therapeutic drug development grows, there is a need to for robust, reproducible, and well-defined scale–up and manufacture processes to generate well characterised material for clinical trials
Editorial Article: Improved LC-MS analysis of oligonucleotides with next-generation chromatography
Watch this on-demand webinar to learn how metal interactions with oligonucleotides impact LC-MS performance, sensitivity and reproducibility
07 Jan 2021
Dr. Martin Gilar, Scientific Fellow at Waters
Accelerated development of oligonucleotides for both therapeutic and diagnostic applications is driving a need for more precise and productive analytical testing of these molecules. One challenge is that oligonucleotides are susceptible to metal interactions that can negatively impact separations performance, reproducibility and sensitivity. To counter the variability caused by these metal interactions, analytical scientists routinely condition or passivate their LC systems/columns to block sites of non-specific adsorption. While conditioning does improve performance and consistency, its effect wears off over time, so repeated conditioning is required to maintain consistent levels of p
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