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Membraneless organelles in cells contain high concentrations of semi-extractable RNAs, which could serve as potential biomarkers and drug targets. However, the identification and characterization of these RNAs have been limited. Japanese researchers have now developed a novel bioinformatic pipeline to define and analyze semi-extractable RNAs, which has led to the identification of over 1000 RNAs involved in membraneless organelle formation. This study paves the way for future investigations into RNA-centric phase separations.

Takeshi chujoMichiaki hamadaChao zengTetsuro hiroseNucleic acids researchBioinformatics laboratoryUniversity computational bio bigData open innovation laboratoryOsaka universityNippon medical schoolSustainable development goals sdgsMolecular biology society of japanInstitute forFaculty of life sciencesKumamoto universityTransdisciplinary research initiatives