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Return on investment from the research that we do, if we dont fund the research we lose that fund and investment. You probably have examples of human benefits from the scientific research, which is foregone human costs, and you probably also pay some attention to the countrys Global Competitiveness in this field. If you could comment on those three areas on what you think is the payback for investment, or if you want to put it contrarily, not funding research. Dr. Collins i appreciate the opportunity to talk about those consequences. Put up another graph which reveals the difficulties that are present in this country beginning back in 2003. What i am showing you the opportunity that an investigator that comes to nih with their best ideas has of getting funded. Most Research Done in this country and our nations finest universities is supported by an age nih. That has been in the space of 2535 success rate. 13. That means two thirds of the people are sent away. Now it is about one in six

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