Science s COVID-19 reporting is supported by the Heising-Simons Foundation
ILLUSTRATION: STEPHAN SCHMITZ/FOLIO ART
In March 2020, as the scope of the COVID-19 pandemic was coming into view, Jen Nwankwo and colleagues turned a pair of artificial intelligence (AI) tools against SARS-CoV-2. One newly developed AI program, called SUEDE, digitally screens all known druglike compounds for likely activity against biomolecules thought to be involved in disease. The other, BAGEL, predicts how to build inhibitors to known targets. The two programs searched for compounds able to block human enzymes that play essential roles in enabling the virus to infect our cells.
While SUEDE sifted through 14 billion compounds in just hours and spit out a hit, BAGEL made equally fast work of designing a lead. Nwankwo, CEO of a Massachusetts biotech startup called 1910 Genetics, asked a chemical company partner to synthesize the compounds. A week or so later, her team received the orders, added each compou
Science’s COVID-19 reporting is supported by the Heising-Simons Foundation.
In March 2020, as the scope of the COVID-19 pandemic was coming into view, Jen Nwankwo and colleagues turned a pair of artificial intelligence (AI) tools against SARS-CoV-2. One newly developed AI program, called SUEDE, digitally screens all known druglike compounds for likely activity against biomolecules thought to be involved in disease. The other, BAGEL, predicts how to build inhibitors to known targets. The two programs searched for compounds able to block human enzymes that play essential roles in enabling the virus to infect our cells.
While SUEDE sifted through 14 billion compounds in just hours and spit out a hit, BAGEL made equally fast work of designing a lead. Nwankwo, CEO of a Massachusetts biotech startup called 1910 Genetics, asked a chemical company partner to synthesize the compounds. A week or so later, her team received the orders, added each compound in turn to human cells, and learned
Over 20 dead, millions struggle without power as cold snap grips US
Agencies
February 17, 2021
Washington, Feb 17: Millions were left without power as a winter storm gripped the southern and central United States on Tuesday with record-low temperatures in ill-prepared areas, and a tornado claiming three lives.
More than 20 storm-related deaths have been registered so far, including in traffic accidents in Texas, Kentucky and Missouri, according to local media.
In hardest-hit Texas where freezing conditions prompted utility companies to implement rotating blackouts a woman and girl died from carbon monoxide poisoning after using a car to generate heat, according to NBC News.
ago while in the custody of antigadhafi brigades. human rights watch is calling on the libyan national council to investigate this. conditions in syria are getting too dangerous for the u.s. ambassador. the state department has pulled ambassador robert ford out of syria citing what it calls credible threats against his personal safety. u.s. officials say an armed pro-government mob attack ford an some colleagues in an embassy convoy last month. ford has been an outspoken critic of the syrian government s violent crack dourn on protesters. u.s. officials say they don t know when it will be safe for ford to return to syria. a growing danger in the skies with more people on the ground shining hand-held lasers into airline cockpits. it usually happens while planes are taking off or landing. the most dangerous times for pilots to be distracted or even temporarily blinded. the faa reports more than 2,700 laser incidents so far this year. nearly ten times the number reported in
antigadhafi brigades. human rights watch is calling on the libyan national council to investigate this. conditions in syria are getting too dangerous for the u.s. ambassador. the state department has pulled ambassador robert ford out of syria citing what it calls credible threats against his personal safety. u.s. officials say an armed pro-government mob attack ford an some colleagues in an embassy convoy last month. ford has been an outspoken critic of the syrian government s violent crack dourn on protesters. u.s. officials say they don t know when it will be safe for ford to return to syria. a growing danger in the skies with more people on the ground shining hand-held lasers into airline cockpits. it usually happens while planes are taking off or landing. the most dangerous times for pilots to be distracted or even temporarily blinded. the faa reports more than 2,700 laser incidents so far this year. nearly ten times the number reported in 2005. there are new stiff pe