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Intravenous Vitamin C for Patients Hospitalized With COVID-19

Two randomized clinical trials were harmonized to compare the effect of vitamin C vs control on outcomes in hospitalized patients with COVID-19 who were critica

United statesNew delhiSaudi arabiaKrung thep mahanakhonWestern australiaCity ofUnited kingdomNational universitySan franciscoSouth australiaNew zealandNorthern irelandFrance generalWellington hillsNorthern territoryAr riya

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on t

Eteläuomen läiSaudi arabiaSri lankaUniversity of minnesotaUnited statesSan franciscoNew south walesCity ofUnited kingdomKrung thep mahanakhonBritish columbiaFrance generalNew zealandWestern australiaNorthern irelandSouth australia

Conditional Power

This JAMA Guide to Statistics and Methods article examines conditional power, calculated while a trial is ongoing and based on both the currently observed data

Rogerj lewisBenjaminr savilleBerry consultantsConditional powerAre conditional powerBayesian predictive probabilitiesWas conditional power usedDoes conditional power affect

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial | Critical Care Medicine | JAMA

This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-te

United kingdomSouth australiaFrance generalCity ofBritish columbiaUnited statesWestern australiaSan franciscoNew zealand generalNew zealandEstado de pernambucoNational universityEteläuomen läiSao pauloSri lankaAr riya

Adjustment for Baseline Characteristics in Randomized Clinical Trials

This Guide to Statistics and Methods provides an overview of the use of adjustment for baseline characteristics in the analysis of randomized clinical trials an

Larsw andersenRogerj lewisAarhus university hospitalEuropean medicines agencyDrug administrationDepartment of anesthesiologyBaseline adjustmentBaseline patient characteristicsBaseline characteristicsWas adjustmentBaseline characteristics doneSequential organ failure assessmentIntensive care

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