1. Low-dose amitriptyline was associated with a marked decrease in IBS-SSS score at 6 months compared to placebo. 2. There were 5 serious adverse reactions (2 in the amitriptyline group and 3 in the placebo group). Evidence Rating Level: 1 (Excellent) Study Rundown: Irritable bowel syndrome (IBS) is a functional disorder that is managed through