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Molecular jackhammers eradicate cancer cells by vibronic-driven action

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12 J cm−2, 80 mW cm−2 for 2.5 min), resulting in complete eradication of human melanoma cells in vitro. Also, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vib

Ayala orozcoNano lettJ raman spectroscQuantum electronYagci acarRaman spectrosc

Kerr-induced synchronization of a cavity soliton to an optical reference

The phase-coherent frequency division of a stabilized optical reference laser to the microwave domain is made possible by optical-frequency combs (OFCs)1,2. OFC-based clockworks3–6 lock one comb tooth to a reference laser, which probes a stable atomic transition, usually through an active servo that increases the complexity of the OFC photonic and electronic integration for fieldable clock applications. Here, we demonstrate that the Kerr nonlinearity enables passive, electronics-free synchronization of a microresonator-based dissipative Kerr soliton (DKS) OFC7 to an externally injected reference laser. We present a theoretical model explaining this Kerr-induced synchronization (KIS), which closely matches experimental results based on a chip-integrated, silicon nitride, micro-ring resonator. Once synchronized, the reference laser captures an OFC tooth, so that tuning its frequency provides direct external control of the OFC repetition rate. We also show that the stability of the

Dissipative kerrQuantum electronPhotonics rev

All-analog photoelectronic chip for high-speed vision tasks

Photonic computing enables faster and more energy-efficient processing of vision data1–5. However, experimental superiority of deployable systems remains a challenge because of complicated optical nonlinearities, considerable power consumption of analog-to-digital converters (ADCs) for downstream digital processing and vulnerability to noises and system errors1,6–8. Here we propose an all-analog chip combining electronic and light computing (ACCEL). It has a systemic energy efficiency of 74.8 peta-operations per second per watt and a computing speed of 4.6 peta-operations per second (more than 99% implemented by optics), corresponding to more than three and one order of magnitude higher than state-of-the-art computing processors, respectively. After applying diffractive optical computing as an optical encoder for feature extraction, the light-induced photocurrents are directly used for further calculation in an integrated analog computing chip without the requirement

Data center deep learning product performanceInternational symposium on computer architectureInternational conference on computer visionInternational solidComputer visionSolid state circuitsPerformance extreme computing conferenceQuantum electronPattern recognitionSolid state circuits conferenceCenter deep learning productAnnual international symposiumComputer architecture

A graphene temporary tattoo measures blood pressure

A graphene temporary tattoo measures blood pressure
scitation.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scitation.org Daily Mail and Mail on Sunday newspapers.

Nikolai korotkovAmerican institute of physicsRoozbeh jafari texasam universityRoozbeh jafariDeji akinwandeQuantum electronCircuits systPhysics today

Intellectual Ventures is awarded $6 5M in trade secrets case

Intellectual Ventures is awarded $6 5M in trade secrets case
geekwire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from geekwire.com Daily Mail and Mail on Sunday newspapers.

King countyUnited statesFred sharifiMcnaul ebel nawrot helgrenRachel cannaraBrian hollowayGreg hollonGeorge finkleVenture advanced physics lab in bellevuePhysics labNational institute of standardsKing county superior courtIntellectual venturesIntellectual ventureIntellectual venture advanced physics labNational institute