Corning Incorporated today announced the launch of its HepGo™ Assay-ready 3D liver spheroid kit, the first plug-and-play solution to include 96 pre-plated primary human hepatocyte (PHH) spheroids in a single-spheroid microplate (one uniform spheroid per well) and HepGo Hepatocyte companion cell culture media.
The new biology of 21st century- Can India Innovate in these interesting times?
The new biology of 21st century- Can India Innovate in these interesting times?
17 May 2021 | Views
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Dr Nirmalya Kumar (see London Business of Economics-Talk-You Tube) in his famous 2012 TEDx talk claimed that India innovates invisibly in all walks of Business including Pharma and Biotech.
Our experience has been that Modern Biology broken down as academic research and Translational sciences poses two different Challenges for India. Indian Academia is not fine tuned to churn out Quality PhDs to research and develop Translational Sciences like Modern OMICS and Integrated OMICS.
A new study describes a synthetic peptide used as a platform to generate protective adaptive cellular immunity to the virus in rhesus macaques, which are the gold standard for preclinical testing in humans.
Primary vs Secondary Assays in Preclinical Testing
Before compounds can be used as medicines, they must go through rounds of testing. These can be separated into preclinical testing and clinical testing. Assays used in preclinical testing seek to test if the compound could elicit the relevant response; first, high-throughput assays are used to select a smaller number of compounds, then those that show promise are screened further to investigate the mechanism of action.
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What are the differences between primary and secondary assays used during preclinical testing?
During the preclinical testing phase of drug discovery, compounds go through a variety of assays to determine their potential as a safe drug for the treatment of the disease in question.
Preclinical Testing for Vaccines
Preclinical testing occurs before clinical trials can be conducted. The goal of preclinical trials is to assess the potential toxicity of a new therapeutic drug using either human cell cultures or animals before the medicine can be tested “in vivo” in human participants.
Preclinical testing is required to demonstrate the safety of new vaccines before they can be tested on humans. In most cases, preclinical testing is extensive in order to gain sufficient data to reliably indicate not just the safety of a new vaccine, but also its potential efficacy, toxicity, and pharmacokinetic properties. In addition, preclinical trials allow scientists to model for potential drug-target interactions.