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Promising First Results With DNA Editing to Lower LDL

The first-in-human HEART-1 trial of in vivo DNA editing called VERVE-101, shows reductions in LDL and PCSK9 protein in patients with familial hypercholesterolemia.

Philadelphia
Pennsylvania
United-states
American
Andrew-bellinger
Karol-watson
Amgen
Novartis
American-heart-association
Verve-therapeutics
American-heart
Lipids

Cholesterol-Lowering Gene Therapy Shows Early Promise

People given the highest doses of a CRISPR-based gene therapy saw a noticeable drop in their levels of LDL-C, which can help cause heart disease.

United-states
American
Eli-lilly
Andrew-bellinger
American-heart-association-scientific-sessions
Verve-therapeutics
American-heart-association
Scientific-sessions
Gene-therapy
Cholesterol
Familial-hypercholesterolemia
Health

Study identifies nearly 100 abdominal aortic aneurysm risk genes

The largest genetic analysis of abdominal aortic aneurysm (AAA) carried out to date has identified almost 100 new risk variants linked to the disorder. The study also highlighted a possible therapeutic target for this pathology that, at the moment, has no treatment.

Aneurysm
Abdominal-aortic-aneurysm
Aaa
Pcsk9
Cholesterol
University-of-michigan
University-of-pennsylvania

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