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Gene Editing Experiment Halted as Patient Gets Weird Side Effects

The experimental biotech startup Verve Therapeutics has paused the first phase of a buzzy human gene-editing trial due to strange side effects in a patient, according to a report from Bloomberg. The trial in question — dubbed the "Heart-1" trial — is the company's attempt to use gene editing to reduce heart-attack-causing cholesterol in patients […]

Verve therapeuticsHeart attackVldl cholesterolVerve therapeuticsFamilial hypercholesterolemiaGene editingSide effectsTrial participantsHuman trial

LetsGetChecked Launches myGeneticScreen, a Genetic Testing Service Designed to Deliver Personalized, Actionable Insights into Predisposition for Inherited Cancers and Cardiovascular Diseases

LetsGetChecked Launches myGeneticScreen, a Genetic Testing Service Designed to Deliver Personalized, Actionable Insights into Predisposition for Inherited Cancers and Cardiovascular Diseases
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United statesNew yorkUnited kingdomAvni santaniPeter foleyCenters for diseaseGenetic testing service designed to deliver personalizedProduct serviceGetchecked launchesGenetic testing service designedDeliver personalizedActionable insightsInherited cancersDisease controlHereditary breastOvarian cancer

Study reveals low utilization of PCSK9 inhibitors in high-risk patients

A new study published in Circulation: Cardiovascular Quality and Outcomes from the Family Heart Foundation -; a patient-centered research and advocacy nonprofit organization dedicated to improving the lives of families impacted by inherited lipid disorders and LDL-cholesterol -; revealed that utilization of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) to reduce low-density lipoprotein cholesterol (LDL-C) remains low among high-risk patients.

United statesDianee macdougallUs food drug administrationFh foundationFamily heart foundationCardiovascular qualityVice presidentBlood cholesterolDrug administrationCardiovascular diseaseFamilial hypercholesterolemiaMetabolic disease

Urgent need for improved detection of pediatric familial hypercholesterolemia worldwide

1. 92.4% of children in high-income countries had heterozygous familial hypercholesterolemia compared to 48.0% in non-high-income countries. 2. The majority of patients with confirmed heterozygous familial hypercholesterolemia were not on any lipid-lowering medication. Evidence Rating Level: 2 (Good) Study Rundown: Familial hypercholesterolemia affects more than 450,000 children worldwide each year, yet only a small proportion

Rating levelYear follow upBetween octCardiovascular risk factorsCoronary artery diseaseCoronary artery disease cadFamilial hypercholesterolemiaFamilial hypercholesterolemia fhHeterozygous familial hypercholesterolemiaVldl cholesterolChronic disease

Familial Hypercholesterolemia May Double Coronary Heart Disease Risk in Moderately Elevated LDL-C

However, the association between familial hypercholesterolemia variants and coronary heart disease slightly weakened after adjusting for baseline low-density lipoprotein cholesterol (LDL-C) level and became statistically insignificant after adjusting for cumulative past LDL-C exposure.

Artery risk development in young adultsCardiovascular health studyAtherosclerosis riskCoronary artery risk developmentYoung adultsFramingham heart study offspringJackson heart studyMulti ethnic studyFamilial hypercholesterolemiaCoronary heart diseaseLdl cLow density lipoprotein cholesterolJama cardiology