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Australian lungfish has largest genome of any animal sequenced so far

Paulo Oliveira / Alamy The Australian lungfish has the largest genome of any animal so far sequenced. Siegfried Schloissnig at the Research Institute of Molecular Pathology in Austria and his colleagues have found that the lungfish’s genome is 43 billion base pairs long, which is around 14 times larger than the human genome. Advertisement Its genome is 30 per cent larger than that of the previous record holder: the axolotl, a Mexican amphibian that the team sequenced in 2018. The researchers used high-powered computer sequencers to piece together the lungfish genome. To account for inherent errors that the sequencers introduce, they used multiple copies of the genome, each fragmented into small pieces of DNA. After all the fragments were sequenced, the team used algorithms to reassemble the pieces into a complete genome.

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