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New antibiotic kills pathogenic bacteria, spares healthy gut microbes

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.

United statesPaul hergenrotherJessica holmesMatt sinclairRebecca ultrichEmad tajkhorshidMichelle hasselChao wenHyang yeon leeRoyj carver biotechnology centerCenters for diseaseUniversity of illinois urbana champaignDisease controlAntibiotic resistance threatsIllinois urbana champaignChris fields

Scientists develop antibiotic that spares healthy gut bacteria

Previous research has suggested that common antibiotics can disturb the gut microbiome.

Paul hergenrotherUniversity of illinois urbana champaignIllinois urbana champaign

Novel Antibiotic Kills Pathogenic Bacteria but Spares Healthy Gut Microbes

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut.

Paul hergenrotherUniversity of illinois urbana champaignIllinois urbana champaign

Antibiotic Slays Gram-Negative Bacteria, Spares Commensals in Mice

Antibiotic Slays Gram-Negative Bacteria, Spares Commensals in Mice
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United statesPaul hergenrotherUniversity of illinois urbana champaignIllinois urbana champaign

Smart antibiotic can kill deadly bacteria while sparing the microbiome

Compound called lolamicin targets a group of harmful microbes but does not disturb those that live peacefully in the gut. Compound called lolamicin targets a group of harmful microbes but does not disturb those that live peacefully in the gut.

New jerseyUnited statesPaul hergenrotherSebastian hillerUniversity of illinois at urbana champaignDr tony brain science photo libraryUniversity of baselZemer gitai at princeton universityDrug administrationScience photoZemer gitaiPrinceton university

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