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Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.

United statesPaul hergenrotherJessica holmesMatt sinclairRebecca ultrichEmad tajkhorshidMichelle hasselChao wenHyang yeon leeRoyj carver biotechnology centerCenters for diseaseUniversity of illinois urbana champaignDisease controlAntibiotic resistance threatsIllinois urbana champaignChris fields