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Two children with lung cancer in Japan acquired the tumour cells from their mothers during or shortly before birth – an incredibly rare way of developing the disease.
Chitose Ogawa at the National Cancer Center Hospital in Tokyo and her colleagues made the discovery while sequencing the DNA of the children’s tumours for a prospective clinical trial.
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The first boy was diagnosed with lung cancer at 23 months old, while the second boy was 6 years old when he developed chest pain, leading doctors to discover a tumour in his left lung.
Both mothers turned out to have cervical cancer: the mother of the first boy was diagnosed three months after the birth and the mother of the second boy was diagnosed following delivery.