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OSU COVID research gets national attention through dance
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IMAGE: The nucleocapsid phosphoprotein (blue) of SARS-CoV-2 (N) (grey) plays critical roles in multiple processes of the SARS-CoV-2 infection cycle, including replication and transcription, and packaging and protecting the genomic RNA. view more
Credit: OSU College of Science
CORVALLIS, Ore. - Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein s interactions with SARS-CoV-2 genetic material.
The virus nucleocapsid protein, or N protein, is a prime target for disease-fighting interventions because of the critical jobs it performs for the novel coronavirus infection cycle and because it mutates at a comparatively slow pace. Drugs and vaccines built around the work of the N protein carry the potential to be highly effective and for longer periods of time - i.e., less susceptible to resistance.
Cleveland-Cliffs, one of the Calumet Region s largest industrial employers, forecasts it will pull in about $3.5 billion in earnings before interest, taxes, depreciation and amortization this year if prices hold up.
The Cleveland-based steelmaker, which bought ArcelorMittal USA and AK Steel last year, projects it will bring in $500 million in EBITDA in the first quarter and $1.2 billion in EBITDA in the second quarter of 2021. The projections assume hot-rolled coil prices in the United States will continue to average $975 per ton for the rest of the year.
Cleveland-Cliffs plans to report its first-quarter earnings on April 22.
Last year, the steelmaker pulled in $353 million in EBITDA but posted a loss of $81 million because of $186 million in costs related to acquisition, severance and inventory step-up. It posted a strong fourth quarter in which it completed its acquisition of ArcelorMittal USA, pulling in a profit of $74 million on $286 million in EBITDA.
OSU study of key COVID-19 protein a step toward new drugs, vaccines
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