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 E-Mail IMAGE: The nucleocapsid phosphoprotein (blue) of SARS-CoV-2 (N) (grey) plays critical roles in multiple processes of the SARS-CoV-2 infection cycle, including replication and transcription, and packaging and protecting the genomic RNA. view more  Credit: OSU College of Science CORVALLIS, Ore. - Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein s interactions with SARS-CoV-2 genetic material. The virus nucleocapsid protein, or N protein, is a prime target for disease-fighting interventions because of the critical jobs it performs for the novel coronavirus infection cycle and because it mutates at a comparatively slow pace. Drugs and vaccines built around the work of the N protein carry the potential to be highly effective and for longer periods of time - i.e., less susceptible to resistance.

University of oregonOregonUnited statesOregon state universityElisar barbarJames prellPatrick reardonJoaquin rodriguezPhillip zhuAmber rollandHeather masson forsytheZhenyuSeth pinckneyRichard cooleyMj murdock charitableDivision of molecular