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Late-toxicity burden high among survivors of high-risk neuroblastoma

CHICAGO — Survivors of high-risk neuroblastoma face a substantial burden of late toxicity, according to study results presented at ASCO Annual Meeting.Prevalence of some late effects vary by treatment received, findings showed.

University of chicagoUnited statesTarao hendersonBymark leiserOren becherMindy valcarcelChidlren oncology groupNational academies of medicineSciences committee on disabilityNational academiesSciences committeeYoung adult survivorship centerOncology groupOncology group based

Combination therapy shows preliminary antitumor activity in pediatric neuroblastoma

The combination of olaparib and the investigational ATR inhibitor ceralasertib induced antitumor responses in children and adolescents with DNA repair-deficient tumors, according to phase 1 results of the AcSé-ESMART trial.The data, presented at American Association for Cancer Research Annual Meeting, also showed ceralasertib (AZD6738, AstraZeneca) plus olaparib (Lynparza, AstraZeneca) — a

United statesUnited kingdomSusanne gatzOren becherMindy valcarcelTimothy yapFondation gustave roussyBydrew amorosiCancer research united kingdomLeukaemia groupGenomic sciencesFrench institut national de cancerUniversity of birmingham institute cancerAmerican association for cancer research annual meetingLittle princess trust children cancerAmerican association

Nanoparticles Target Medulloblastoma Tumor to Improve Drug Therapy and Reduce Toxicity

Nanoparticles Target Medulloblastoma Tumor to Improve Drug Therapy and Reduce Toxicity
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Praveen rajuOren becherSteven ravitchDaniel hellerIcahn school of medicine at mount sinaiNational institutes of healthJack martin fund division of pediatric hematologyResearchers at mount sinai health systemHead of the cancer nanomedicine laboratoryFoundation game changer grantMemorial sloan kettering cancer centerMount sinai health systemSpinal tumor centerMount sinai kravis childrenNature materialsIcahn school

Improved Anti-Tumor Drug Delivery Across Blood–Brain Barrier

Researchers have developed a new drug delivery approach that uses nanoparticles to enable more effective and targeted delivery of anti-cancer drugs to treat brain tumors in children.

Praveen rajuOren becherSteven ravitchDaniel hellerNational institutes of healthTechnology networkJack martin fund division of pediatric hematologyMount sinai health systemHead of the cancer nanomedicine laboratoryFoundation game changer grantMemorial sloan kettering cancer centerSpinal tumor centerMount sinai kravis childrenAssociate professorIcahn schoolCancer nanomedicine laboratory

Jack Martin Fund Gives $3 5 Million to Mount Sinai Kravis Children s Hospital to Establish State-of-the-Art Child and Adolescent Imaging Center

Jack Martin Fund Gives $3 5 Million to Mount Sinai Kravis Children s Hospital to Establish State-of-the-Art Child and Adolescent Imaging Center
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New yorkUnited statesMark zellerAlan feldmanLisam satlinOren becherHerberth lehmanMargaret pastuszkoChris mongeluzoFernando ferrerBlau centerLucy clark department of pediatricsJack martin fundDivision of pediatric hematologyTumor centerImaging center