<p>Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis. Scientists think that with the help of “matchmaker” molecules called molecular glue degraders, this machinery could be hijacked to control proteins involved in diseases like cancer. But only a few of these glue degraders have been discovered so far—and mostly by chance.</p>
<p>Zuzanna Kozicka, as a Ph.D. student at Friedrich Miescher Institute in Basel, Switzerland, embarked on a deliberate search for these glues with her team and identified a novel class of molecular glue degraders with more than 40 chemically diverse members. Kozicka, who is now a postdoctoral fellow at the Dana Farber Cancer Institute, also took a closer look at the crystal structures of the complexes that these molecules induce to glean clues about how they carry out their matchmaking services. She is the grand prize winner in molecular medicine of the <a h
New Molecular Glue Degraders Target Troublesome Proteins aaas.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aaas.org Daily Mail and Mail on Sunday newspapers.
Clone is an odd term culturally. Thanks to science fiction on one side and ethical hysteria on the other, people tend to overstate the meaning of it. Back before genomes, to clone a gene was to basically discover it - it meant you found the stretch of DNA encoding that gene - but now we know where almost all of the genes are.
Florian Schmidt is the grand prize winner of the 2022 Science & SciLifeLab Prize for Young Scientists for developing a breakthrough technology that records microbiotic activity.
EMBL and SciLifeLab foster new connections miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.