Johns Hopkins University: Molecular Alteration May Be Cause — Not Consequence — of Heart Failure indiaeducationdiary.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from indiaeducationdiary.in Daily Mail and Mail on Sunday newspapers.
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Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Their research found that elevated levels of O-GlcNAc made mice more prone to heart failure, but lowering levels of O-GlcNAc restored the animals risk of death and heart function to normal. Together, the investigators say, the new findings, described online in the April 27th issue of the journal
Editorial Article: Glycoproteomics: A powerful new biomarker domain debuts in translational research
Guest editor Dr. Klaus Lindpaintner discusses how innovations in glycoprotein characterization are advancing protein biology and medicine
15 Mar 2021
Dr. Klaus Lindpaintner, CSO and CMO at InterVenn Biosciences
In this guest editorial, we hear from Dr. Klaus Lindpaintner, CSO and CMO at InterVenn Biosciences, about how artificial intelligence and machine learning tools have reduced labor-intensive glycoprotein characterization and how these innovative steps are helping play a pivotal role in the progression of structural biology and medicine.
Watson, Crick, and the genetic blueprint
Ever since Watson and Crick first described the molecular structure of nucleic acids in their seminal 1953
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Palo Alto, CA Understanding how plants respond to stressful environmental conditions is crucial to developing effective strategies for protecting important agricultural crops from a changing climate. New research led by Carnegie s Zhiyong Wang, Shouling, Xu, and Yang Bi reveals an important process by which plants switch between amplified and dampened stress responses. Their work is published by
Nature Communications.
To survive in a changing environment, plants must choose between different response strategies, which are based on both external environmental factors and internal nutritional and energy demands. For example, a plant might either delay or accelerate its lifecycle, depending on the availability of the stored sugars that make up its energy supply.