Single-dose synthetic psilocybin improves the core symptoms of treatment-resistant depression, while other frequently measured parameters only contribute noise to the outcome, phase 2 data show.
Over the past decade, suicide rates decreased by almost 20% in Europe, but there was high variability between counties and by gender, a large analysis shows.
ECT in older patients with refractory depression and bipolar disorder has been linked to cognitive improvement, allaying fears that the treatment could have a deleterious impact in this patient population.
For older patients with resistant depression who fail to respond to antidepressants, the addition of atypical antipsychotic aripiprazole is superior to switching antidepressants, new research suggests.