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Genetic risk scores do not have a place in public health screening

Researchers said the scoring system led to false positives and ‘performed poorly when predicting if a person would develop common diseases.

United kingdomCity ofAroon hingoraniNick waldMichael inouyeSam lambertJasmine grattonNicholas waldDusko ilicNational institute for healthInstitute of cardiovascular scienceBiomedical research centreInstitute of health informaticsBritish heart foundationUnited kingdom researchCare research

Genetic risk scores not useful in predicting disease

Genetic risk scores not useful in predicting disease
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United kingdomNick waldCare researchInstitute of health informaticsBiomedical research centreUnited kingdom researchOur future healthBritish heart foundationNational institute for healthInstitute of cardiovascular scienceFuture healthProfessor aroon hingoraniCardiovascular sciencePolygenic score catalogProfessor sir nicholas waldHealth informatics

Genetic risk scores not useful in predicting

<p>The new study, published in <em>BMJ Medicine</em>, looked at 926 polygenic risk scores for 310 diseases. It found that, on average, only 11% of individuals who develop disease are identified, while at the same time 5% of people who do not develop the disease test positive. Unaffected people usually outnumber those affected which results in far more false than true positive predictions.</p>

United kingdomNick waldUniversity college londonInstitute of cardiovascular scienceUnited kingdom researchCare researchOur future healthInstitute of health informaticsBritish heart foundationMethod of researchNational institute for healthBiomedical research centreFuture healthProfessor aroon hingoraniCardiovascular sciencePolygenic score catalog

Genetic risk scores do not have a place in public health screening | East London and West Essex Guardian Series

Researchers said the scoring system led to false positives and ‘performed poorly’ when predicting if a person would develop common diseases.

City ofUnited kingdomJasmine grattonAroon hingoraniMichael inouyeDusko ilicNicholas waldNick waldSam lambertBiomedical research centreCare researchInstitute of health informaticsUniversity of cambridgeUnited kingdom researchUniversity college londonBritish heart foundation

Genetic risk scores not useful in predicting disease, study argues

Genetic risk scores not useful in predicting disease, study argues
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Aroon hingoraniNick waldOur future healthUniversity college londonInstitute of health informaticsInstitute of cardiovascular scienceFuture healthProfessor aroon hingoraniCardiovascular sciencePolygenic score catalogProfessor sir nicholas waldHealth informaticsJasmine grattonSir nick wald