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To get ahead of variants, Covid drug makers use evolution as guide- STAT

A representation of monoclonal antibodies binding to antigens on a cell surface. Anna Tanczos/Wellcome Images Before becoming a Covid-19 drug, each candidate was just a tiny fragment of someone’s immune system, part of a swarm of Y-shaped proteins unleashed to try to keep the coronavirus from invading more cells. If the person recovered, these antibodies might end up in a blood sample in a lab. Some proved more effective than others. Yet even as researchers pinpointed the best of the bunch as possible medications, they knew their power could wane: What worked against the coronavirus as it was last year could falter as the pathogen evolved.

World s largest clinical trial for COVID-19 treatments expands internationally

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