Fatty liver disease (steatotic liver disease, SLD for short) is increasingly causing failure of the liver as a vital organ. A team led by researchers has now discovered that a saturated fatty acid in blood vessels leads to the production of the signalling molecule SEMA3A, which closes the windows in the blood vessels. This hinders the transport of fat from the liver to the adipose tissue. The researchers report that the windows open again and the fat in the liver is reduced when SEMA3A is inhibited.
Innate immune cells including macrophages and neutrophils have unique properties that allows them to quickly accumulate in large numbers at the site of infection or injury. A new study establishes that macrophage in the adult ischemic muscle induce a phenotype switch into mural cells to support restoration of functional blood flow and thereby promote healing. This finding pinpoints macrophages as a potential target for therapeutically enhancing vascular integrity and healing of ischemic injuries.
Studies from multiple UChicago experts show that while GLP-1RA drugs are extremely effective for weight loss and Type 2 diabetes treatment, there s no one-
Studies from multiple UChicago experts show that while GLP-1RA drugs are extremely effective for weight loss and Type 2 diabetes treatment, there s no one-